3. Isaac W. Sprague
Isaac W. Sprague was famously known as “human skeleton” who born at Massachusetts in 1841. Sprague began losing weight drastically when he was 12, although he grew normally in his early childhood. At the age 24, just after the war ended, Sprague joined a circus sideshow for the first time and P.T. Barnum hired him the following year. He married Tamar Moore and both have three healthy and normal sons. Sprague weighed of only 43 pounds in the age of 44 and unfortunately, he died of asphyxia in poverty.