2. Anthony Hopkins as Hannibal Lecter (Silence of the Lambs)
A villain is even more threatening if he or she happens to be a genius with a sadistic streak. Hannibal Lecter is a doctor of psychiatry so he knows how to get into people’s head. If that wasn’t bad enough, he also has a taste for human flesh. Enough said. This is one villain you don’t want to cross.
