4. John William Meriwether (Loss: $4.6 billion)
Meriwether is considered as a pioneer in fixed-income arbitrage and an American hedge-fund executive. He established the LTCM (Long-Term Capital Management) at Connecticut in 1994, but the company collapsed four years later. In 1999, Meriwether founded another hedge fund trading company, the JWM Partners LLC. From $250 million in 1997, the company amassed about $3 billion in 2007, but unfortunately the financial crisis in 2007-2009 ruined his firm badly, causing huge financial loss.